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Into the blue: gene duplication and loss underlie colour vision adaptations in genome comparison humans and chimps deep-sea chimaera, the elephant shark Callorhinchus milii Genome Research 2009 19: 415-426. Lasso penalized regression is particularly advantageous when the number of predictors far exceeds the number of observations. Abstract Motivation: In ordinary regression, imposition of lasso penalty makes continuous model selection straightforward. Individuals can use this topography to find sites that share their genomes. At some point, however, these cells begin to differentiate, or change into specific cell types.